Peptic ulcer disease is a condition characterized by defects in the mucous membrane of the gastrointestinal organs, ranging in size from 0.5 cm to 3 cm or more. The most common forms include stomach ulcers or duodenal ulcers, as well as peptic and gastroduodenal ulcers.
The primary cause of this disease is an imbalance between aggressive factors (hydrochloric acid, pepsin) and the protective mechanisms of the mucous membrane. Contributing factors include Helicobacter pylori infection, improper diet, stress, alcohol abuse, and prolonged use of certain medications. Key symptoms include:
- Pain in the upper abdomen, often occurring after meals or on an empty stomach.
- Nausea, sometimes accompanied by vomiting.
- Periodic heartburn and belching.
- Loss of appetite and weight loss.
Stomach ulcers are more common than duodenal ulcers, though defects may sometimes be found in both organs simultaneously. The disease may be classified as newly diagnosed or recurrent (chronic).
Chronic stomach ulcers can lead to complications such as bleeding, perforation of the stomach or intestinal wall, and stenosis. Therefore, it is important to seek medical attention at the first signs of the disease.